Crucell Terug naar discussie overzicht

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1. [verwijderd] 19 januari 2006 12:08

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   Beste Gert,
   
   Hier is het abstract van het bewuste artikel:
   
   The ongoing outbreak of avian influenza A virus
   (subtype H5N1) infection in Asia is of great concern
   because of the high human case fatality rate and the
   threat of a new influenza pandemic. Case reports in
   humans and felids suggest that this virus may have
   a different tissue tropism from other influenza viruses,
   which are normally restricted to the respiratory
   tract in mammals. To study its pathogenesis in
   a mammalian host, domestic cats were inoculated
   with H5N1 virus intratracheally (n
   3), by feeding
   on virus-infected chicks (n
   3), or by horizontal
   transmission (n
   2) and examined by virological
   and pathological assays. In all cats , virus replicated
   not only in the respiratory tract but also in multiple
   extra-respiratory tissues. Virus antigen expression
   in these tissues was associated with severe necrosis
   and inflammation 7 days after inoculation. In cats
   fed on virus-infected chicks only, virus-associated
   ganglioneuritis also occurred in the submucosal
   and myenteric plexi of the small intestine, suggesting
   direct infection from the intestinal lumen. All
   cats excreted virus not only via the respiratory tract
   but also via the digestive tract. This study in cats
   demonstrates that H5N1 virus infection causes systemic
   disease and spreads by potentially novel
   routes within and between mammalian hosts. (Am
   J Pathol 2006, 168:176–183; DOI: 10.2353/ajpath.2006.050466)
   
   Groeten :) Frank
2. [verwijderd] 19 januari 2006 12:16

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   Sorry, de auteurs vergeten:
   
   Guus F. Rimmelzwaan, Debby van Riel, Marianne Baars, Theo M. Bestebroer, Geert van Amerongen, Ron A.M. Fouchier, Albert D.M.E. Osterhaus, and Thijs Kuiken
   From the Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
   
   Daar staat "onze" Appie ook bij nl.
   
   Groeten :) Frank
   
3. [verwijderd] 19 januari 2006 16:01

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   INTERVIEW-Bird flu deaths raise need for Euro taskforce
   19 Jan 2006 14:35:52 GMT
   
   Source: Reuters
   LONDON, Jan 19 (Reuters) - Deaths in Turkey from avian flu have increased the need for a European task force that can be rapidly deployed to fight the virus that has spread from Asia to Europe's doorstep, a leading expert said on Thursday.
   
   The bird flu virus has killed four children in Turkey. An 11 year-old who died on Wednesday could become the fifth victim if laboratory tests confirm she died from the H5N1 strain.
   
   Dr Albert Osterhaus, a virologist at Erasmus Medical Center in the Netherlands and the chairman of the European scientific working group on influenza, believes more co-ordination is needed in Europe to tackle bird flu.
   
   "I think we should form a European influenza task force that brings together all our knowledge, so that if you have outbreaks in the future you could form delegations to work together with local experts in the area where it occurs," he told Reuters during a conference in London.
   
   The task force would include a network of laboratories throughout Europe and bring together virologists, doctors, epidemiologists and experts in agriculture and human and animal health.
   
   "It would be good to take advantage of all the combined expertise ... with the threat of avian flu being on the doorstep of Europe at the moment."
   
   French Prime Minister Dominique de Villepin has also expressed the need for a European intervention force to halt the spread of bird flu.
   
   Osterhaus said the task force would work in close co-ordination with the World Health Organisation (WHO), the Food and Agriculture Organisation (FAO) and the OIE, the world organisation for animal health.
   
   MORE TO BE WORRIED ABOUT
   
   Osterhaus, who was speaking at a meeting of bird flu experts, said ducks and geese are important reservoirs of the virus. He also called for the establishment of a repository of viruses, in addition to H5N1, that could potentially develop into a pandemic strain in humans .
   
   "We're all talking about H5, but there is much more than H5 to be worried about," he said.
   
   Given that migratory birds are suspected of playing an important role in the spread of the virus, Osterhaus said countries such as Iran, Iraq, Syria, Greece and east Africa should be on the alert.
   
   "Many of the birds migrate to east Africa at the moment," he added.
   
   "The crucial question is how long can the migratory birds carry the virus without dying? There are a couple of groups, including our own, who are doing experiments to actually find that out."
   
   Osterhaus warned against placing too much emphasis on laboratory analysis of samples of H5N1 from the Turkish children that showed a mutation that could make it more capable to use human cell receptors.
   
   "We have seen that mutation in the past and it has not led to the emergence of a pandemic virus, in terms of the virus being capable of spreading from human to human efficiently," he added.
   
   "We don't know what, at the end of the day, will determine that the virus becomes transmissible between humans."
   
   www.alertnet.org/thenews/newsdesk/L19...
4. [verwijderd] 19 januari 2006 16:19

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   Sorry ik kon dit bericht ook niet laten passeren:
   
   Report: Avian flu may not show symptoms
   
   Jan. 19, 2006 at 9:33AM
   
   World Health Organization scientists are concerned that a growing number of people are turning up who have been exposed to avian flu but showed no symptoms.
   The organization said four people who culled sick birds in Japan and two attendants caring for infected tigers in Thailand were found to have antibodies to the virus but showed no symptoms.
   That leads to concern the H5N1 virus could be more widespread among humans than scientists are aware, The Wall Street Journal reported Thursday.
   Hundreds of undetected cases would mean "there's that much more opportunity for this virus to learn to be transmissible," said Scott Dowell, head of global disease detection for the Centers for Disease Control and Prevention in Atlanta. "With every case, we worry about the possibility of the virus acquiring the ability to transmit from human to human."
   There have been 148 confirmed cases of avian flu in humans since it appeared in Southeast Asia at the end of 2003. Of those, more than 70 deaths have been reported.
   The disease is principally spread by infected wildlife to domestic fowl, from which humans acquire it by handling or eating the meat.
   
   www.washtimes.com/upi/20060119-092015...
   
   
5. [verwijderd] 19 januari 2006 22:49

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   quote:

   flosz schreef:

   Flu Virus Resistant to 2 Drugs, CDC Says
   
   By DANIEL YEE, Associated Press Writer
   2 hours, 58 minutes ago
   
   ATLANTA - The government, for the first time, is urging doctors not to prescribe two antiviral drugs commonly used to fight influenza after discovering that the predominant strain of the virus has built up high levels of resistance to them at alarming speed.
   
   
   A whopping 91 percent of virus samples tested by the Centers for Disease Control and Prevention this flu season proved resistant to rimantadine and amantadine, a huge increase since last year, when only 11 percent were.
   
   The discovery adds to worries about how to fight bird flu should it start spreading among people. Health officials had hoped to conserve use of two newer antiviral drugs, Tamiflu and Relenza, because they show activity against bird flu, unlike the older drugs.
   news.yahoo.com/s/ap/20060115/ap_on_he...
   _ylt=AoIjPl393LfnLDZk4RxUdkWs0NUE;_ylu=X3oDMTA3czJjNGZoBHNlYwM3NTE-
   

   The Lancet Early Online Publication, 19 January 2006
   
   DOI:10.1016/S0140-6736(06)67970-1
   
   Antivirals for influenza in healthy adults: systematic review
   T Jefferson a , V Demicheli a, D Rivetti a, M Jones b, C Di Pietrantonj a and A Rivetti a
   
   Summary
   Background
   Use of antivirals is recommended for the control of seasonal and pandemic influenza. Our aim was to review the evidence of efficacy, effectiveness, and safety of registered antivirals against naturally occurring influenza in healthy adults.
   
   Methods
   We searched various Databases to October, 2005, and contacted manufacturers and corresponding authors. We included randomised controlled trials comparing prophylactic (n=27) or treatment (n=27) efficacy against symptomatic or asymptomatic influenza. We did a meta-analysis and expressed prophylactic efficacy as a proportion (1–relative risk [RR]). For treatment trials, because of inconsistent and non-standardised reporting, we expressed continuous outcomes either as means or as hazard ratios.
   
   Findings
   We included 51 reports of 52 randomised controlled trials. Amantadine prevented 61% (95% CI 35–76) of influenza A cases and 25% (13–36) of cases of influenza-like illness, but caused nausea (OR 2·56, 1·37–4·79), insomnia and hallucinations (2·54, 1·50–4·31), and withdrawals because of adverse events (2·54, 1·60–4·06). There was no effect on asymptomatic cases (RR 0·85, 0·40–1·80). In treatment, amantadine significantly shortened duration of fever compared with placebo (by 0·99 days, −1·26 to −0·71), but had no effect on nasal shedding of influenza A viruses (0·93, 0·71–1·21). The fewer data for rimantadine showed comparable effects. In prophylaxis, compared with placebo, neuraminidase inhibitors have no effect against influenza-like illness (1·28, 0·45–3·66 for oral oseltamivir 75 mg daily, 1·51, 0·77–2·95 for inhaled zanamivir 10 mg daily). Higher doses appear to make no difference. The efficacy of oral oseltamivir 75 mg daily against symptomatic influenza is 61% (15–82), or 73% (33–89) at 150 mg daily. Inhaled zanamivir 10 mg daily is 62% efficacious (15–83). Neither neuraminidase inhibitor appeared effective against asymptomatic influenza. Oseltamivir induces nausea (OR 1·79, 1·10–2·93), especially at higher prophylactic doses (2·29, 1·34–3·92). Oseltamivir in a post-exposure prophylaxis role has a protective efficacy of 58·5% (15·6–79·6) for households and from 68% (34·9–84·2) to 89% (67–97) in contacts of index cases. In influenza cases, compared with placebo the hazard ratios for time to alleviation of symptoms were 1·33, 1·29–1·37 for zanamivir; 1·30, 1·13–1·50 for oseltamivir provided medication was started within 48 h of symptom onset. Viral nasal titres were significantly diminished by both drugs (weighted mean difference −0·62, −0·82 to −0·41). Oseltamivir at 150 mg daily was effective in preventing lower respiratory tract complications in influenza cases (OR 0·32, 0·18–0·57). We could find no credible data on the effects of oseltamivir on avian influenza.
   
   Interpretation
   The use of amantadine and rimantadine should be discouraged. Because of their low effectiveness, neuraminidase inhibitors should not be used in seasonal influenza control and should only be used in a serious epidemic or pandemic alongside other public-health measures.
   
   Affiliations
   
   a Cochrane Vaccines Field, ASL 20, 15100 Alessandria, Italy
   b Queensland Clinical Trials Centre, University of Queensland, Queensland, Australia
   
   www.thelancet.com/journals/lancet/art...
   
6. [verwijderd] 20 januari 2006 07:47

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   Bird flu
   The Times January 20, 2006
   
   More dangerous strain of bird flu
   By Mark Henderson
   
   
   Preparations for a flu pandemic are being undermined because health authorities have become obsessed with a single strain of the virus at the expense of a potentially more dangerous version, a leading scientist said yesterday.
   
   
   Chris Potter, of the University of Sheffield, said that although the H5N1 avian flu virus is clearly a threat, its spread has led researchers to ignore another strain that history suggests is more likely to trigger a pandemic.
   
   The spread of the H5N1 virus among birds, and its exceptional virulence when it infects people, has led scientists to concentrate surveillance and research on this strain of influenza to the exclusion of others, he told an international flu conference in London.
   
   Historical evidence, however, indicates that viruses from the H5 family have never before triggered a pandemic, while H2 influenza strains pose an underestimated hazard to human health.
   
   Although he accepted the necessity of watching H5N1 closely and developing vaccines, Professor Potter said that scientists must be careful not to focus their efforts too closely on a strain that may turn out to be the wrong one to worry about. Monitoring programmes need to be widened to ensure that the first signs of a resurgent H2 strain are also picked up, he said.
   
   
   
   www.timesonline.co.uk/article/0,,25149-2000879,00.html
   
7. [verwijderd] 20 januari 2006 09:12

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   Goed nieuws zo voor het weekend:
   
   Red wine found to be good against flu
   
   www.chinaview.cn 2006-01-20 05:14:11
   
   ROME, Jan. 19 (Xinhuanet) -- Italian researchers have confirmed that red wine is not only good for combating cardiovascular conditions and diseases like Alzheimer's, but also effective against flu.
   
   A report from Italy's Higher Health Institute, Rome University and the National Research Council found that a molecule found in red wine, is capable of blocking the flu virus from mutating process.
   
   The report is important because of the global alert over avian flu, which many experts fear could mutate and cause a pandemic. At present there is no known pharmaceutical product which can effectively block the flu virus.
   
   Scientists believe that the 1918 "Spanish Flu", which killed millions of people around the world, was caused by a mutated avian flu virus.
   
   The Italian study, which has been published by the Journal of Infectious Diseases, was based on tests on cell cultures and then on live animals.
   
   According to the researchers, they were able to reduce the flu mortality rate in mice by 60 percent.
   
   "This discovery is very important because it increases the possibility of combating the virus and has proved effective against all different types of flu," researchers said.
   
   A flood of scientific studies has already shown that drinking two glasses of red wine a day helps prevent diseases like Alzheimer's and Parkinson's as well as cholesterol-related cardiovascular conditions.
   
   There has been extensive research in Italy on the medicinal benefits of wine and it has been discovered that white wine also contains a disease-fighting molecule.
   
   Drinking white wine appears to be good for the lungs, too.
   
   According to a June 2002 study released by the University of Buffalo, people who drink white wine regularly have healthier lungs than people who do not.
   
   news.xinhuanet.com/english/2006-01/20...
   
8. [verwijderd] 20 januari 2006 09:24

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   Vanavond zuurkool met een glas rode wijn!!!!!!
9. [verwijderd] 20 januari 2006 09:30

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   flosz,
   Dank voor dit bericht. Weet jij nog welke strain Sanofy Crucell gaan testen in Noorwegen ??
   Het is niet H5N1.
10. [verwijderd] 20 januari 2006 10:00

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    'Red wine found to be good against flu '
    
    Ik zorg voor voldoende voorraad en zal de flu lallende weerstaan(ook meer fun dan Tamiflu).
    Maar wat geef ik mijn kids? Jip&Janneke Champagne?
    
    Ben benieuwd of ik een wijnvoorraadje kan aanleggen op kosten van mijn ziektekostenverzekeraar; weet iemand of zijn/haar verzekering dit dekt, want ik kan evt. nog switchen voor maart geloof ik...
    
    mvg ivet
    
    
12. [verwijderd] 20 januari 2006 10:01

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    quote:

    wpw schreef:

    flosz,
    Dank voor dit bericht. Weet jij nog welke strain Sanofy Crucell gaan testen in Noorwegen ??
    Het is niet H5N1.
    

    H7N1 o.i.d. (er kwam een 7 in voor)
    
    mvg ivet
13. Hans Igor 20 januari 2006 10:45

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    quote:

    Gert50 schreef:

    Goed nieuws zo voor het weekend:
    
    Red wine found to be good against flu
    
    www.chinaview.cn 2006-01-20 05:14:11
    
    ROME, Jan. 19 (Xinhuanet) -- Italian researchers have confirmed that red wine is not only good for combating cardiovascular conditions and diseases like Alzheimer's, but also effective against flu.
    
    

    Heb ik het niet altijd gezegd: Go Grand Cru.....
    Hans Igor
14. [verwijderd] 20 januari 2006 11:22

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    quote:

    Gert50 schreef:

    Goed nieuws zo voor het weekend:
    
    Red wine found to be good against flu
    
    "" According to the researchers, they were able to reduce the flu mortality rate in mice by 60 percent. """
    
    news.xinhuanet.com/english/2006-01/20...
    
    

    Als ik dit lees dan moet ik denken aan die reclame van die hoelahoepende cavia.... muizen aan de rode wijn.....lol....
    
    Babs
    
    
15. [verwijderd] 20 januari 2006 11:36

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    BF komt dichterbij: Griekenland. Als het koud weer wordt/blijft kan het virus langer overleven. Beneden 4 graden C langer dan 30 dagen in vogeluitwerpselen.
    
    Bird flu is confirmed in Greece
    
    Romanian authorities are taking no risks with the potentially lethal virus
    Greece has become the latest country to report a case of bird flu as the virus appears to spread across Europe.
    The country's agriculture ministry said a form of the virus had been found in a turkey on a farm on the Aegean Sea island of Oinouses.
    
    Twelve swans have also tested positive for bird flu in a second cluster in Romania.
    
    And the European Commission has ordered urgent tests on dead birds found in Croatia.
    
    At this stage, neither of the new outbreaks in Greece or Romania have been confirmed as the lethal H5N1 form of the bird flu virus, which has been linked to more than 60 human deaths in Asia.
    
    However, tests are continuing, and the Greek outbreak is known to involve the H5 strain, of which the deadly form is a member.
    
    Meanwhile in Asia, the deadly H5N1 strain has been detected in sparrows in Thailand.
    
    An outbreak of H5N1 was confirmed in Romania last week.
    
    A British lab tested samples taken from swans which died in ponds near the Romanian village of Maliuc in the Danube Delta.
    
    news.bbc.co.uk/1/hi/world/europe/4348...
    
16. [verwijderd] 20 januari 2006 11:44

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    quote:

    invoorentegenspoed schreef:

    [quote=wpw]
    flosz,
    Dank voor dit bericht. Weet jij nog welke strain Sanofy Crucell gaan testen in Noorwegen ??
    Het is niet H5N1.
    [/quote]
    
    H7N1 o.i.d. (er kwam een 7 in voor)
    
    mvg ivet
    

    Klopt!
    
    
    Brussels, 27 October 2005
    
    European scientists develop human vaccine against H7N1 avian flu virus
    Supported by the EU Research Framework Programme, influenza experts from the UK, Italy and Norway, working with vaccine researchers from Sanofi Pasteur in France, have developed another human candidate vaccine for pandemic human flu, targeting the H7N1 avian flu virus. Following this research breakthrough, it is planned that this new vaccine, for the first time targeted against H7N1 virus, will go into clinical trials in Spring 2006 (it will be called ‘RD-3’). Most vaccine development has centred on H5N1 thus far, which is the highly pathogenic form of the avian influenza (“bird flu”) dominating the news at present. However, a report from the FLUPAN research project in last week’s Journal of Infectious Disease (JID) notes that also the H7 virus can spread from poultry to humans. These important research activities on vaccines are part of the overall set of measures undertaken by the Commission in order to tackle avian influenza and the potential emergence of pandemic influenza in humans.
    
    The vaccine research project is called FLUPAN is funded by the European Union to demonstrate European capacity to produce a safe and effective vaccine against highly pathogenic avian influenza viruses. The FLUPAN consortium consists of six partners: Health Protection Agency, UK; Istituto Superiore di Sanita, Italy; National Institute for Biological Standards and Control, UK; Sanofi Pasteur, France, the vaccines business of the Sanofi-Aventis Group; University of Bergen, Norway; University of Reading, UK.
    
    The project began in September 2001 by selecting a highly pathogenic H7N1 virus as a potential pandemic virus. This virus caused lethal outbreaks in Italian poultry in 1999 and was related to the H7N7 poultry virus in the Netherlands.
    
    As the H7N1 virus was too dangerous for direct use in standard influenza vaccine production, it was modified to make it safe using a process called ‘reverse genetics’. The ‘custom-built’ RD-3 vaccine, passed international safety tests and is now being used by Sanofi Pasteur to produce a vaccine. It is the first vaccine not to use eggs in its production by using the reverse genetics technique.
    
    The risk of H7 emerging as a pandemic influenza strain is considered to be lower than for H5N1. Nonetheless, the technological progress achieved through the H7 FLUPAN research ensures that the project will be a valuable resource for pandemic vaccine development in the future. The research appears in the October 15 issue (p. 1318) of The Journal of Infectious Diseases, which can be found at www.journals.uchicago.edu/JID/journal/.
    
    An expert meeting last week in Brussels investigated further research needs in prevention and therapies against avian and possible human pandemic influenza. The experts concluded that a rapid mobilization of extraordinary research efforts is required to address the needs for prevention through improved vaccines. These research efforts and clinical studies are part of the wide range of actions and measures undertaken or proposed by the European Commission in order to address the current avian influenza situation and the potential emergence of pandemic influenza in humans.
    
    The fight against the disease needs to be tackled at the source, i.e. in animals, while at the same time, a major effort is needed to ensure the protection of humans through the availability of highly performing pandemic influenza vaccines.
    For more information on the EU-funded research project FLUPAN:
    
    www.nibsc.ac.uk/spotlight/flupan.html
    For further information on influenza:
    
    europa.eu.int/comm/dgs/health_consume...
    
    europa.eu.int/rapid/pressReleasesActi...
    
    ************************************************
    Sanofi pasteur’s pandemic preparedness in France
    
    Research program initiated since 2002
    NIAID research grant: Egg-based H5N1 vaccine production
    FLUPAN EU/NIBSC contract: Cell-based H7N1 vaccine production. Originally Vero based. Currently, production of H7N1 vaccine in PER.C6 cells (Crucell NV) for clinical study with and without adjuvant. Currently at preclinical stage with safety and immunogenicity Phase 1 study in Q2, 2006.
    66.249.93.104/search?q=cache:Iig6qnxP...
    
17. [verwijderd] 20 januari 2006 11:56

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    klasse flosz, ik zocht ook naar dit artikel.
    Zoeken op internet is ook een kunst die jij heel goed verstaat!
    
    mvg ivet(had ik het toch goed geraden)
18. [verwijderd] 20 januari 2006 12:03

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    Roche said tests on animals showed that Tamiflu could work against the current strain of the disease.
    *************************************
    
    Tamiflu works against deadly bird flu strain -study
    20 Jan 2006 10:35:41 GMT
    
    Source: Reuters
    
    
    ZURICH, Jan 20 (Reuters) - Tamiflu, the drug which many governments have stockpiled to ward off a deadly bird flu pandemic, appears to be an effective antidote to the disease if administered early enough, its maker Roche Holding AG said.
    
    In the wake of a study published in the Lancet medical journal, which said that drugs like Tamiflu should only be used in serious epidemics, Roche said tests on animals showed that Tamiflu could work against the current strain of the disease.
    
    "The results suggest that Tamiflu can prevent H5N1 mortality in animals," the company said in a statement.
    
    "However, further studies are needed to identify the optimal dose of Tamiflu administered later (24 and 48 hours) after the infection with the virulent H5N1 virus," the firm said.
    
    The study evaluated the efficacy of Tamiflu given to ferrets 4 hours after infection with current strain of the disease.
    www.alertnet.org/thenews/newsdesk/L20...
19. [verwijderd] 20 januari 2006 12:05

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    komt op mij over dat er tegenstrijdige berichten zijn m.b.t. werking Tamiflu...(of vergis ik me?)
    
    ivet
20. [verwijderd] 20 januari 2006 12:08

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    quote:

    Gert50 schreef:

    BF komt dichterbij: Griekenland.
    Bird flu is confirmed in Greece
    
    

    Excuses: is oud bericht van oktober. Er zijn wel vandaag berichten op de Turkse radio i.v.m. vogelgriep in Griekenland, maar dat is nog niet bevestigd:
    
    Turkish channel, Haberturk had a "flash" report a few minutes ago saying BF was seen in many provinces of Greece and that there was a secret meeting last night with govnt officials and army staff about it.
21. [verwijderd] 20 januari 2006 12:22

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    quote:

    invoorentegenspoed schreef:

    komt op mij over dat er tegenstrijdige berichten zijn m.b.t. werking Tamiflu...(of vergis ik me?)
    
    ivet
    

    Klopt idd. Verschillende postings in dit draadje mbt Tamiflu/Relenza.
    
    Wijntje klinkt prettiger, en o.a. door de OPC blijf je er ook lekker "jong" (fris&fruitig) bij.
    Gr.(Pretpakket, vinotherapie)