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  7. [verwijderd] 9 oktober 2007 17:01

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    New bird flu strain dangerous to humans
    A new strain of the bird flu virus spreading around the world is more infectious to humans, a study lead by a U.S. researcher has found.

    Led by Yoshihiro Kawaoka of the University of Wisconsin-Madison, the new study found the H5N1 virus has apparently mutated into a new strain that increases the risk of a human pandemic due to its increased level of communicability, The Independent said Saturday.

    Kawaoka said the new strain does not represent a fully pandemic strain of the virus, but warned the mutated virus has been found in both Europe and Africa.

    "The viruses circulating in Europe and Africa all have this mutation," the doctor said. "So they are the ones that are closer to human-like flu."

    Since the virus was first reported in 2003, 329 people worldwide have been infected according to World Health Organization figures.

    Those figures also show that of those infected during that time period, 201 have died as a result.

    The British newspaper said health groups worldwide have prepared for a possible pandemic by collecting anti-flu drugs and preparing emergency treatment plans.


  12. [verwijderd] 10 oktober 2007 07:41

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    WORCESTER, Mass., Oct. 9, 2007 (PRIME NEWSWIRE) -- Generex Biotechnology Corporation (NasdaqCM:GNBT - News) announced today that Dr. Minzhen Xu, Vice President of Biology at Antigen Express, Inc., the Company's immunotherapy subsidiary, will make a presentation at a scientific symposium on the Company's strategy for converting cancer cells into potent tumor vaccine cells

    Dr. Xu will present ``Inhibition of MHC class II-associated Invariant Chain Generates Potent Tumor Cell Vaccine'' at the 12th World Congress on Advances in Oncology to be held at the Creta Maris Hotel, Hersonissos, Crete, Greece, to be held from Oct. 11 through the 13th. The conference will focus on a variety of aspects of tumor biology and therapeutics. Dr. Xu will co-Chair and present in the Experimental Therapeutics/Vaccines section on Oct. 13th.

    The talk by Dr. Xu will present pre-clinical studies that Antigen Express has performed in preparation for clinical trials in China. Robust anti-tumor immunity has been demonstrated in a variety of mouse tumor models as well as safety using the RNAi approached developed at Antigen Express. The trials in China will be performed in collaboration with Dr. Daopei Lu and the Beijing Daopei Hospital in Beijing, China. Dr. Lu is a world-renowned hematologist-oncologist who has conducted many clinical trials and has authored over 200 articles in peer-review journals.

    The strategy being developed by Antigen Express is to force tumor cells to express tumor associated antigens in a way that that makes them more visible to the immune system. This is done by suppressing expression of the MHC class II-associated invariant chain in tumor cells using RNAi. MHC class II molecules are naturally expressed in many cells of the body including some types of cancer cells. The invariant chain prevents class II molecules from associating with antigenic peptides in the cytoplasm of cells (where tumor associated antigens are found) and presenting them for recognition by T helper cells. Antigen-specific stimulation of T helper cells is pivotal in allowing the immune system to recognize novel pathogenic agents. While a number of groups have demonstrated the efficacy of this strategy in pre-clinical models, Antigen Express has developed proprietary methods using RNAi that make this approach feasible in the clinic.

    Antigen Express is focused on developing active immunotherapy products for serious diseases and unmet medical needs. Currently the company has an immunotherapeutic peptide in Phase II clinical trials for breast cancer and in Phase I trials for the potentially pandemic H5N1 avian influenza.

  17. [verwijderd] 11 oktober 2007 07:57

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    Canadian food agency says infected chickens on Sask. farm have been destroyed
    THE CANADIAN PRESS


    REGINA - About 50,000 chickens infected with avian flu on a Regina-area farm have been destroyed, the Canadian Food Inspection Agency announced Wednesday.

    In a news release, the agency said the birds were killed with carbon dioxide gas and their carcasses were buried in a remote area of the farm.

    "Normal decomposition of the bird carcass following burial effectively deactivates the avian influenza virus," said the release.

    The next step will be the cleaning and disinfection of all barns, vehicles, equipment and tools on the property.

    "Providing that no new cases of infection are found in the area, the producer will be able to introduce new birds onto the property after cleaning and disinfection have been completed," said the CFIA.

    The agency said it would monitor any new flock to make sure they are virus-free.

    In addition, the farmer will be compensated for the market value of all the birds destroyed, as well as any costs incurred in their destruction.

    The highly pathogenic H7N3 strain of avian influenza had been found on the farm about 40 kilometres north of Regina more than a week ago.

    The strain is the same one behind a 2004 outbreak in British Columbia that saw 17 million chickens destroyed, but is not the strain dangerous to humans.

    None of the chickens from the farm got into the food chain, but even if they had, CFIA officials said the disease would not make the meat unsafe for humans.

    After the virus was discovered, the U.S. Department of Agriculture moved swiftly to ban all imports of live birds, including chickens and turkeys, from Saskatchewan and all unprocessed bird products.

    Japan later followed suit.

    The bans, however, were likely to have little effect because the poultry industry in Saskatchewan is relatively small and the United States has not imported any poultry products from the province since 2005, the department said.

    The CFIA said it would continue to monitor another farm in the same area as a precaution.

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